Synthesis of nucleoside 5'-fluoroalkylphosphonates with potential antiviral activity

N. B. Dyatkina, M. V. Yasko, A. A. Arzumanov, A. A. Krayevsky, F. M. Semchenko, O. G. Yeremin, B. I. Martynov

V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova 32, Moscow 117984;@@Research Institute of General Chemical Technology, Entusiastov Ave, Moscow

Abstract: Several 5'-fluoroalkylphosphonates of 3'-azido-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine were synthesized as potential antiviral compounds. Fluoromethyl, difluoromethyl, fluorochloromethyl and vinyl phosphonates were used as phosphonyla-ting components, with dicyclohexylcarbodiimide or triisopropylbenzenesulphonyl chloride as condensing reagents.

Russian Journal of Bioorganic Chemistry 1992, 18 (1):100-106

Full Text (PDF, in Russian)