H-Phosphonates of hydroxysterols as new key compounds for the synthesis of sterol derivatives, of mono-, oligonucleotides and their analogues
A. G. Venyaminova, Z. A. Sergeyeva, V. Z. Bashirova
Novosibirsk Institute of Bioorganic Chemistry, Siberian Division, Academy of Sciences of the USSR, Novosibirsk
Abstract: A simple and effective method of synthesis of mono- and oligonucleotide sterol derivatives via hydroxysterol H-phosphonates is examplified by attaching cholesterol and testosterone to the 5'-end of properly protected ribonucleosides or immobilized decanucleotides of deoxyribo-and ribo-series and their 2'-O-methyl-analogues.
Russian Journal of Bioorganic Chemistry 1991, 17 (9):1294-1296