Mutations in homologous proteins confirm the existence of the amino acids interaction code
G. I. Chipens
Institute of Organic Synthesis, Latvian Academy of Sciences, Riga
Abstract: To verify the existence of a code of interaction between the residues of amino acids and antiamino acids (L.B. Mekler, 1969), natural amino acids were divided into groups, each having common antiamino acids. Using data (M.O. Dayhoff, Atlas of Protein Sequences and Structures, 1978) on point mutations in homologous proteins, it is shown that during evolution the substitutions of amino acids with similar polarities dominated within any separate group. Group I: C, R, SI, C, W/A, T, P, S2. Group II (with two subgroups): D, N, H, Y/V, M, I; E, K, Q/L, F.
Russian Journal of Bioorganic Chemistry 1991, 17 (9):1284-1288