Acyclic nucleoside analogs. I. Development of allenic nucleoside derivative's synthesis
A. V. Tsytovich, M. V. Kochetkova, E. V. Kuznetsova, B. I. Mitsner, V. I. Shvets
M. V. Lomonosov Institute of Fine Chemical Technology, Moscow
Abstract: A modified scheme for the adenallene and cytallene synthesis with the total yield of 30–35% is suggested. 1-Benzoyloxy-4-bromo-2-butyne is used as an alkylating agent. Methods of the acetylene-allene transition of hydroxybutynic derivatives of nucleic acid bases in the presence of potassium tert-butylate or sodium dimsylate are investigated.
Russian Journal of Bioorganic Chemistry 1991, 17 (8):1086-1093