Directed introduction of amino group into internucleotide phosphate of oligodeoxyribonucleotides. Synthesis of biotinylated oligonucleotides

V. P. Veiko, K. I. Ratmanova, A. S. Oslpov, M. T. Bulenkov, V. V. Pugachev

All-Union Institute of Genetics and Selection of Industrial Microorganisms, Moscow

Abstract: An efficient procedure for solid-phase synthesis of amino-oligonucleotides has been developed, leading to direct introduction of an aliphatic primary amino group at the in-ternucleotide phosphate. Amino-oligonucleotides were successfully used for preparation of biotinylated oligonucleotides.

Russian Journal of Bioorganic Chemistry 1991, 17 (5):685-689

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