Antigenic structure of the foot-and-mouth disease virus. VI. Functional sites of the immunodominant region of VP1 protein of the foot-and-mouth disease virus O1K and A22 strains

V. M. Gel'fanov, L. A. Grechaninova, E. S. Kan, A. V. Yarov, A. Yu. Surovoy, O. M. Vol'pina, A. V. Chepurkin, V. T. Ivanov

M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR, Moscow

Abstract: B- and T-epitopes have been localized within the protective fragments of VP1 protein, viz., 136152 of the O1K strain and 135159 of the A22 strain of the foot-and-mouth disease virus (FMDV). Antibodies eliciting after immunization of various animals with the 135159 A22 peptide are directed to different sites of the peptide. Immunogenicity of fragments of the 135159 A22 peptide on mice correlates with their activity on T-cells of the same animals and protective activity on guinea pigs. The investigations were carried out using synthetic fragments of the 136152-O1K and 135159-A22 peptides.

Russian Journal of Bioorganic Chemistry 1991, 17 (5):596-605

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