Identification of a small protective epitope in the Lassa virus nucleoprotein

A. B. Moshnikova, A. T. Kozhich, A. G. Krasko, L. D. Tchikin, N. D. Barkar, V. T. Ivanov

M. M. Shtmyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR, Moscow; Byelorussia Research Institute of Epidemiology and Microbiology, Minsk

Abstract: Several peptides from Lassa virus glyco- and nucleoproteins were predicted as probable T-cell epitopes. Their synthesis was performed by solid phase method. The study of possible protective effect in vivo with Lassa-sensitive CBA mice revealed protective epitope within the 277303 nucleoprotein region. Further studies reduced the protective epitope structure to the 287300 nucleoprotein fragments.

Russian Journal of Bioorganic Chemistry 1991, 17 (4):572-573

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