Use of mass-spectrometry with chemical ionization in screening of antibacterial antibiotics with broad spectrum of activity (aminoglycosides and macrolides)
B. V. Rozynov, Yu. V. Zhdanovich, L. I. Nasonova
M. M. Shemyakin Institute of Bioorganic Chemistry, Academyof Sciences of the USSR, Moscow; National Research Institute of Antibiotics, Ministry of Medical Industry of the USSR, Moscow
Abstract: It is shown that mass-spectrometry with ammonia desorption chemical ionization (ADCI) can be used for identification of aminoglycosides and macrolides at the initial stages of screening. ADCI can also be used for selection of strains which form the lowest amounts of by-products, as well as for optimization of biosynthetic conditions.
Russian Journal of Bioorganic Chemistry 1991, 17 (4):561-566