Mass spectrometry method ERIAD in the structural study of anthracycline antibiotics

O. A. Mirgorodskaya, E. N. Olsufyeva, E. R. Matweeva, A. V. Podtelezhnikov

Institute of Analytical Instrumentation, Academy of Sciences of the USSR, Leningrad, * Institute of New Antibiotics, Academy of Medical Sciences of the USSR, Moscow

Abstract: Fragmentation of antibiotics daunorubicin, carminomycin, doxorubicin and their semisynthetic analogues under conditions of the new mass spectrometry method ERIAD is discussed. Signals of protonated molecular ion (M+H)+ and ions of fragments are present in all the mass spectra. The results are compared with literary data obtained by means of other (EI and FAB MS) mass spectrometry methods.

Russian Journal of Bioorganic Chemistry 1991, 17 (4):556-560

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