Tryptic fragments structure of the black widow spider venom neurotoxin

?. M. Volkova, ?. G. Galkina, ?. ?. Kudelin, E. V. Grishin

M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR, Moscow

Abstract: The N-terminal amino acid sequence of a neurotoxin from the venom of Latrodectus mactans tredecimguttatus (α-latrotoxin) was determined. Latrotoxin was subjected to the tryptic cleavage and total or partial amino acid sequences of 25 peptides were established. In total the tryptic fragments contained 252 amino acid residues. .Essential structural information on cloning of the latrotoxin structural gene was obtained.

Russian Journal of Bioorganic Chemistry 1991, 17 (4):437-441

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