Code of codon roots determining inter- and intramolecular interaction of amino acids in peptide chains

G. Chipens, N. Ieivina, R. Rudzish

Institute of Organic Synthesis, Latvian Academy of Sciences, Riga

Abstract: To study the recognition processes and interaction of peptides and proteins, a model has been suggested according to which the first steps of complex formation of molecules are defined by G/C and A/U complementarity of codon roots of amino acid forming the molecules contact sites or surfaces. In contrast to amino acid antiamino acid interaction code (L.B. Mekler, 1969), the code of codon roots involves the interaction of amino acids independently of the base structures in nucleotide triplets in positions 1 and 3. The analysis of the spectra of point mutations homologous proteins confirms the possible role of the root code.

Russian Journal of Bioorganic Chemistry 1991, 17 (11):1582-1584

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