Code of codon roots determining inter- and intramolecular interaction of amino acids in peptide chains
G. Chipens, N. Ieivina, R. Rudzish
Institute of Organic Synthesis, Latvian Academy of Sciences, Riga
Abstract: To study the recognition processes and interaction of peptides and proteins, a model has been suggested according to which the first steps of complex formation of molecules are defined by G/C and A/U complementarity of codon roots of amino acid forming the molecules contact sites or surfaces. In contrast to amino acid – antiamino acid interaction code (L.B. Mekler, 1969), the code of codon roots involves the interaction of amino acids independently of the base structures in nucleotide triplets in positions 1 and 3. The analysis of the spectra of point mutations homologous proteins confirms the possible role of the root code.
Russian Journal of Bioorganic Chemistry 1991, 17 (11):1582-1584