Interaction code of polar and apolar amino acids: «ice-breaker» model
G. Chipens, R. Rudzish
Institute of Organic Synthesis, Latvian Academy of Sciences, Riga
Abstract: A novel model for the study of recognition and interaction code of amino acids in peptides, proteins and their complexes has been proposed. The model is designed on the modern notions on the structure and properties of water and hydrophobic bonds. It is assumed that the polar side chains of amino acids during the formation of the hydro-phobic bonds act as “ice-breaker”, thus destroying the organized structure of water (clusters or “icebergs”) around the hydrophobic radicals of amino acids.
Russian Journal of Bioorganic Chemistry 1991, 17 (11):1445-1448