A new class of cardiotonic steroids
A. V. Kamernitzky, I. A. Koutnevich, I. G. Reshetova, E. I. Chernoburova, B. A. Gorshkov, I. A. Gorshkova, I. I. Kapoustina
N.D. Zelinsky Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow; Pacific Institute of Bioorganic Chemistry, Far East Division, Academy of Sciences of the USSR, Vladivostok
Abstract: A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K+-dependent ATPase from rat brain in the 1·10-8–1·10-4 M concentrations. Natural 23-oxogenins from sea star Aslerias amurensis and synthetic monoesters showed the inhibiting activity up to 50–55%. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.
Russian Journal of Bioorganic Chemistry 1991, 17 (1):141-143