Synthesis of phosphoanalogues of histidine and carnosine

A. R. Khomutov

A. N. Bach Institute of Biochemistry, Academy of Sciences of the USSR, Moscow

Abstract: Earlier unknown β-imidazolyl-α-aminoethylphosphonous acid (His-PH) was synthesized by the addition of hypophosphorous acid to the imidazolylacetaldehyde oxime and then converted into βAla-His-PH. Both PH-compounds were oxidized into the corresponding phosphonic acids by treatment with S02C12 in glacial acetic acid.

Russian Journal of Bioorganic Chemistry 1990, 16 (9):1290-1293

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