Automated H-phosphonate synthesis of oligoribonucleotides using 2'-O-tetrahydropyranyl protecting group
A. G. Venijaminova, V. V. Gorn, M. A. Zenkova, N. I. Komarova, M. N. Repkova
Novosibirsk Institute of Bioorganic Chemistry, Siberian Division, Academy of Sciences of the USSR
Abstract: Using N-acyl-5'-O-dimethoxytrityl-2'-O-tetrahy(lropyranyl-3'-H-phosphonates and pivaloyl chloride as activating agent, a series of oligoribonucleotides 6–19 nucleotides long have been prepared on the automatic synthesizer «Victoria» with overall yields 3 –44%.
Russian Journal of Bioorganic Chemistry 1990, 16 (7):941-950