The enzymatic incorporation of paratose residues into O-specific polysaccharides of Salmonella

T. N. Druzhinina, O. V. Sizova, V. N. Shibaev, S. Sh. Rozhnova

N. D. Zelinsky Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow; Central Research Institute of Epidemiology, Ministry of Health of the USSR, Moscow

Abstract: The block mechanism of O-specific polysaccharides biosynthesis was demonstrated for Salmonella nitra (serogroup A) and S. haifa (serogroup B). Due to the moderate specificity of glycosyl transferases from S. nitra, S. typhimurium, S. haifa and S. ken-tucky (serogroup C3) towards the 3,6-dideoxyhexose structure a paratose residue can be-incorporated into the polysaccharide chain instead of an abequose residue, and vice versa.

Russian Journal of Bioorganic Chemistry 1990, 16 (6):816-821

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