MOLECULAR NATURE OF LEISIONS OF THE HRASl ONCOGENS IN HUMAN BREAST CARCINOMAS: GT TRANSVERSION IN THE 12th CODON OF ONE ALLELE WITH THE OTHER ALLELE DELETED

P. G. KNYAZEV, O. M. SEROVA, V. I. BABENKO, I. F. NIKIFOROVA, A. A. GOL'TSOV*, G. F. PLUZHNIKOVA, O. V. PLUTALOV **, Yu. A. BERLIN**, E. I. SCHWARTZ *

N. N. Petrov Institute of Oncology, Ministry of Health of the USSR, Leningrad; *B. P. Konstantinov Institute of Nuclear Physics, Academy of Sciences of the USSR, Gatchina , Leningrad Region; **M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR, Moscow

Abstract: In study of human breast carcinomas, molecular nature of a mutation in one allele of the HRAS1l gene leading to malignization in case of the second allele being deleted is shown to be G→T transversion in the 12th codon of the gene.

Russian Journal of Bioorganic Chemistry 1990, 16 (3):419-423

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