DERIVATIVES OF GANGLIOSIDE GM 3 AND THEIR IMMUNOMODULATING EFFECTS

E. V. DYATLOVITSKAYA, A. B. KOROLEVA, V. S. SUSKOVA, V. I. EMEZ, L.V. SUTYUSHEVA, L. D. BERGELSON

M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR, Moscow

Abstract: The derivatives of ganglioside GM3 NeuLacCer, NeuLacSph and NeuAcLacSphAc -were obtained and their immunomodulating properties studied. These substances are shown to inhibit lymphocyte blasttransformation independently of their ceramide structure. On the contrary, the stimulation by the above GM3-derivatives of Con A-induced T-suppressor activity depends significantly on the structure of their ceramide moiety.

Russian Journal of Bioorganic Chemistry 1990, 16 (3):402-406

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