SYNTHESIS AND STUDY OF CYCLIC ANALOGUES OF ANGIOTENSIN
J. ANCANS, D. BISENIECE, I. VOSEKALNA, N. MYSHLIAKOVA, G. CHIPENS
Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, Riga
Abstract: Five angiotensin cycloanalogues have been synthesised by classical methods of pep-tide chemistry, cyclisation being carried out via pentafluorophenyl esters. Cycloanalogues (I—IV) with a fixed potential turn in the C-terminal part of the angiotensin molecule inferred on the basis of physico-chemical data do not possess angiotensin-like activity. Compounds (V) with enlarged cycle shows decreased pressure effects as compared with angiotensin. By means of circular dichroism chiroptical properties of the compounds in water and ethanol were examined.
Russian Journal of Bioorganic Chemistry 1990, 16 (3):358-369