STUDIES OF ANTIGENIC STRUCTURE OF THE HEPATITIS B VIRUS PROTEINS. I. SYNTHESIS OF PRE-S FRAGMENTS OF THE HEPATITIS B VIRUS ENVELOPE PROTEINS AND THEIR IMMUNOGENICITY

D. E. TSVETKOV, A. V. ILJINA*, S. M. ANDREEV, A. A. SOKOLENKO*, S. P. PAVLIKOV, P. PUMPEN, M. A. NOVIKOV

Institute of Immunology, Health Ministry of the USSR, Moscow; *Institute of Organo Element Compounds, Academy of Sciences of the USSR, Moscow; *" Institute of Epidemiology and Microbiology, Health Ministry of the USSR, Moscow

Abstract: Fragments of hepatitis B virus envelope proteins corresponding to the parts of the pre-S domain were synthesized and immobilised on the carriers with low own immunogenisity. The highest stimulation of the antibody production was observed for the antigens immobilised on microspherical carriers or gelatine modified by H-Gly-Tyr-OH. Among peptides used for immunization, pre-S fragment 134144, conjugated with microspherical carrier, proved to be the most active.

Russian Journal of Bioorganic Chemistry 1990, 16 (2):166-178

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