A new method of the construction of the steroidal polyhydroxylated side chains
V. A. Khripach, R. P. Litvinovskaya, A. V. Baranovsky
Institute of Bioorganic Chemistry, Academy of Sciences of the Byelorussian SSR, Minsk
Abstract: A simple and effective new approach was used for constructing steroidal hydroxylated side chains. The reaction sequence involves cycloaddition of Δ22-steroids with nitrile oxide followed by hydrogenation of the obtained isoxazolines with Raney nickel in the acid medium to afford 22-hydroxy-24-oxo derivatives.
Russian Journal of Bioorganic Chemistry 1990, 16 (12):1700-1701