Synthesis and antitumour activity of new derivatives of anthracycline antibiotics modified in the aglycon moiety
E. N. Olsufyeva
Institute of New Antibiotics, Academy of Medical Sciences of the USSR, Moscow
Abstract: Anthracycline antibiotics are widely used, along with their semisynthetic analogues, in human cancer chemotherapy, are O-glycosides having as aglycon 7,8,9,10-tetrahydrona-phtacenequinone-5,10-with some hydroxy groups, a side chain at C-9 and sugar(s) residues, usually at C-7. The review includes the most important studies on the chemical modification of the aglycon moiety of daunorubicin, doxorubicin and carminomycin& during last ten years.
Activity of the compounds on experimental tumours is described and their structure-activity relationship is discussed.
Russian Journal of Bioorganic Chemistry 1990, 16 (11):1445-1464