New in synthesis of natural and modified oligodeoxyribonucleotides by H-phosphonate method

S. M. Gryaznov, V. K. Potapov

All Union Institute of Biotechnology, 117246 Moscow

Abstract: An efficient method for obtaining oligodeoxyribonucleotides with alkylainino groups joined to internucleotide phosphate groups has been developed. It is shown that inter-nucleotide phosphodiester group does not affect the efficiency; of oligonucleotide synthesis by H-phosphonate method.

Russian Journal of Bioorganic Chemistry 1990, 16 (10):1419-1422

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