Synthesis of lipophilic glycosides of O-(N-acetylglucosaminyl)-(β1→4)-N-acetylmuramoyl-L-alanyl-D-isoglutamine

A. E. Zemlyakov, V. O. Kur'yanov, S. S. Pertel, V. Ya. Chirva, T. M. Andronova

M. V. Frunze Simferopol State University,' M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR; Moscow

Abstract: N-Acyl-ω-aminoalkanols were obtained by N-acylation of 2-aminoethanol-l and 6-aminohexanol-l with hexadecanoic and 2-dodecyltetradecanoic acids and glycosylated with the oxazoline derivative of glucosaminylmuramic acid. The disaccharide glycosides obtained were used to synthesize β-(N-acyl-ω-aminoalkyl)glycosides of GMDP.

Russian Journal of Bioorganic Chemistry 1990, 16 (10):1393-1397

Full Text (PDF, in Russian)