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THE SYNTHESIS OF 6-O-ALKYLGUANOSINE SYNTHONS OF RIBO- AND DEOXYRIBO SERIES FOR THE PHOSPHOTRIESTER SYNTHESIS OF OLIGONUCLEOTIDES
TAKTAKISHVILI M. O., TABDJOUN A., YARTSEVA I. V.*
Tbilisi State University;
*Academy of Medical Sciences of the USSR,
All-Union Cancer Research Centre, Moscow
Abstract: A number of 6-O-alkylsubstituted deoxy- and riboguanosines of potential carcinogenic and mutagenic activity have been synthesized by the reaction of deoxy- and riboguanosine with phenylchlorotyioformate followed by N-isobutyrylation, 5'-dimethoxytritylation and 3'-phosphorylation. The fully protected 6-O-alkyl guanosine-3'-phosphates thus obtained are versatile G-units for the oligonucleotide phosphotriester synthesis.
Russian Journal of Bioorganic Chemistry 1990, 16 (1):59-68