MICROWAVE-ASSISTED SYNTHESIS AND EVALUATION OF INDOLE BASED BENZOFURAN SCAFFOLDS AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS

© 2016 D. Ashok^#, G. Srinivas, A. V. Kumar, and D. M. Gandhi

^#Phone: 91-9391024769; e-mail: ashokdou@gmail.com

Green and Medicinal Chemistry Lab, Department of Chemistry, Osmania University, Hyderabad-500007, India

Received January 10, 2016; in final form, April 21, 2016

DOI: 10.7868/S0132342316050031

A novel series of indole based benzofuran derivatives has been synthesized under microwave irradiation and conventional conditions. The structures of the compounds were established on the basis of ¹H-NMR, ¹³C-NMR, IR and mass spectral data. The analogues were evaluated for their in vitro antimicrobial activity against two gram–positive bacteria, two gram–negative bacteria and two fungal strains. The same series was screened for in vitro antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH). Most of the title compounds exhibited promising antimicrobial and antioxidant activities.

Keywords: indole, benzofuran, Claisen-Schmidt reaction, microwave irradiation, antimicrobial activity, antioxidant activity.

Биоорг. химия 2016, 42 (5): 617-623