IMIDAZO[4,5-a]QUININDOLINES AS HIGHLY EFFECTIVE ANTIBACTERIAL AGENTS
© 2016 Mehdi Pordel*, #, Shirin Ramezani*, Maryam Jajarmi**, and Mina Sokhanvar*
#Phone: +98 0513 8414182; fax: +98 0513 8424020; e-mail: email@example.com
*Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran **Khorasan Razavi Rural Water and Wastewater Co
Received May 20, 2015; in final form, August 28, 2015
Resistance to antimicrobial agents is a concern that exists globally and has a considerable impact on human and animal health, so that the discovery of new antibacterial compounds has become increasingly more important in combating infectious disease. In this paper, imidazo[4,5-a]quinindolines are introduced as new antibacterial agents against Gram-positive and Gram-negative bacteria. These pentacyclic compounds are synthesized by the reaction of N-alkyl-5-nitrobenzimidazoles with 2-(1-alkyl-1H-3-indolyl)acetonitrile under basic conditions in excellent yields. The structures of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass spectral data. The antibacterial activities of the synthesized compounds were screened against standard strains of two Gram-positive and two Gram-negative bacteria using the broth microdilution method. Most of the compounds studied showed promising activities against both types of bacteria.
Keywords: 5-nitrobenzimidazoles, imidazo[4,5-a]quinindoline, Gram-positive and Gram-negative bacteria, antibacterial agents, MIC.
Биоорг. химия 2016, 42 (1): 117-121