A CONVENIENT SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL THIENO[2,3-c]PYRAZOLE COMPOUNDS AS ANTIMICROBIAL AND ANTI-INFLAMMATORY AGENTS

2015 Adel M. Kamal El-Dean, Remon M. Zaki#, Abdullah Y. Abdulrazzaq

#E-mail: remonch2003@yahoo.com

Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt

Received April 3, 2014; in final form June 3, 2014

A new method for synthesizing 4-amino-3-methyl-1-phenyl-1H-5-substituted thieno[2,3-c]pyrazole was reported. The substituted groups at position 5 include carbonitrile, carboxamide, N-phenyl carboxamide, and benzoyl groups. The newly synthesized compounds and their derivatives were characterized by elemental analysis and spectroscopy (IR, 1H NMR, and mass spectra). Furthermore, some of these synthesized compounds were screened against various pathogenic bacterial and fungal strains. The results demonstrate that most of the synthesized compounds possess a significant antibacterial activity against gram-positive and gram-negative bacteria. In addition, most of these compounds showed a remarkable anti-fungal activity. On the other hand, some of the synthesized compounds possess high anti-inflammatory activity, which was demonstrated using the carrageenan-induced rat paw edema assay.

Keywords: synthesis, reactions, thienopyrazole, thienopyrazolopyrimidine, thienopyrazoloimidazolopyrimidine.