SYNTHESIS AND EVALUATION OF IN VITRO ANTIOXIDANT PROPERTIES OF NOVEL 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES

2014 Lakshmi Ranganatha V, Shaukath Ara Khanum#

#Phone: 0091-99018 88755; fax: 08212419239; e-mail: shaukathara@yahoo.co.in

Department of Chemistry, Yuvarajas College, University of Mysore, Mysore, Karnataka, 570005 India

Received July 26, 2013; in final form, October 28, 2013

2,5-Disubstituted 1,3,4-oxadiazole compounds are one of the most attractive heterocyclic compounds for researchers due to their biological activities. In the undertaken research, a number of potential 2,5-disubstituted 1,3,4-oxadiazole analogues were synthesized through multi step reaction and characterized by FT-IR, 1H NMR, mass spectra, and also by elemental analysis. Further benzophenone tagged indole acetohydrazides and 2,5-disubstituted 1,3,4-oxadiazoles were evaluated for antioxidant potential, through different in vitro models such as DPPH, nitric oxide and hydrogen peroxide methods. In the series of compounds some of them had shown good to moderate in vitro antioxidant potential compare to the standard drug ascorbic acid in all the above three methods.

Keywords: antioxidant assay, benzophenone, N-methyl indole, 1,3,4-oxadiazole.

. 2014, 40 (2): 226-233