SYNTHESIS OF SELENIUM-CONTAINING AMINO ACID ANALOGUES AND THEIR BIOLOGICAL STUDY
© 2011 Sh. H. Abdel-Hafez#*,**, H. A. Saad*,***, M. R. E. Aly*,****
*Chemistry Department, Faculty of Science, Taif University, 888, Alhawiya, Taif University, Taif, Kingdom of Saudi Arabia; **Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt; ***Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt; ****Chemistry Department, Faculty of Science, Port Said University, Egypt
Received November 29, 2010; in final form, December 29, 2010
Synthesis of selenium-containing amino acid analogues is described. These compounds were prepared in a concise and short synthetic route in good yields by nucleophilic substitution reaction of pyridineselenol and quinolineselenol derivatives with N-phthaloylglycyl chloride followed by hydrazinolysis. The newly synthesized compounds were screened against different strains of bacteria and fungi.
Key words: pyridineselenol; quinolineselenol; amino acid; anti-bacterial activities; anti-fungal activities.