Positively Charged Acyl Derivatives of Carbohydrates as Promising Transfection Agents
M. A. Maslov1 #, Z. Ya. Al Shoaibi1, T. V. Andryushina1, N. G. Morozova1 and G. A. Serebrennikova1
#Phone: (495) 936-89-03, e-mail: email@example.com
1 Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571, Russia
Received: September 13, 2006; in final form: January 30, 2007
Abstract. A convenient approach to the synthesis of mono-and polycationic glycolipid amphiphiles is suggested. The compounds obtained can be used for studying the structure-activity relationship and determination of the effect of hydrophobic and cationic domains on the transfection efficiency.
Key words: cationic liposomes; genetic therapy ;lipids; transfection
Russian Journal of Bioorganic Chemistry 2007, 33(5): 499-504