Racemic and Optically Active Tocopherol Analogues with a Modified Side Chain: Synthesis and Biological Activity
V. N. Odinokov1 #, A. Yu. Spivak1 and O. V. Knyshenko1
#Fax: (3472) 31-27-50; e-mail: email@example.com
1Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, pr. Oktyabrya 141, Ufa, 450075, Bashkortostan, Russia
Received: September, 5 2006; in final form: December, 11 2006
Abstract. Information on the synthesis and biological activity of natural and synthetic analogues of α-tocopherol with a modified side chain is systematized. These compounds are of interest as vitamin E metabolites, hydrophilic antioxidants, and precursors of drugs with combined pharmacological properties useful in therapy of pathological disorders caused by oxidative stress.
Key words: α-tocopherol, analogues, biological activity, metabolites, synthesis
Russian Journal of Bioorganic Chemistry 2007, 33 (4): 359-375