Review Article

Racemic and Optically Active Tocopherol Analogues with a Modified Side Chain: Synthesis and Biological Activity

V. N. Odinokov^1 #, A. Yu. Spivak¹ and O. V. Knyshenko¹

^#Fax: (3472) 31-27-50; e-mail: ink@anrb.ru

¹Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, pr. Oktyabrya 141, Ufa, 450075, Bashkortostan, Russia

Received: September, 5  2006;  in final form: December, 11  2006

Abstract.  Information on the synthesis and biological activity of natural and synthetic analogues of α-tocopherol with a modified side chain is systematized. These compounds are of interest as vitamin E metabolites, hydrophilic antioxidants, and precursors of drugs with combined pharmacological properties useful in therapy of pathological disorders caused by oxidative stress.

Key words:  α-tocopherol, analogues, biological activity, metabolites, synthesis

Russian Journal of Bioorganic Chemistry 2007, 33 (4): 359-375