Synthesis and Biological Properties of D-Homo-6-Oxa-8α-Analogues of Steroid Estrogens

A. G. Shavva1 #, S. N. Morozkina1, I. V. Ishchenko1, I. I. Eliseev1, S. I. Selivanov1, Sh. N. Abusalimov1, S. S. Selivanov1, I. Yu. Kameneva1 and N. D. Eshchenko1

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1Faculty of Chemistry, St. Petersburg State University, Universitetskii pr. 26, Staryi Petergof, St. Petersburg, 198504, Russia

Received: August 8, 2006; in final form: November 22, 2006

Abstract.  Modifications of D-homo-6-oxa-8α-analogues of steroid estrogens were found to lead to a complete loss of the uterotropic and hypertriglyceridemic activities. These compounds may be promising for the design on their basis of inhibitors of the steroid hormone metabolism and transporters of other compounds to the estrogen target organs.

Key words:  analogues of steroid estrogens devoid of uterotropic and hypertriglyceridemic activities

Russian Journal of Bioorganic Chemistry 2007, 33 (3): 288-292