Cytotoxic Derivatives of (22 R ,23 R )-Dihydroxystigmastane

F. V. Drozdov¹, A. P. Mekhtiev¹, G. E. Morozevich¹, V. P. Timofeev² and A. Yu. Misharin^1 #

^#Phone: (495) 246-58-20; e-mail: alexander.misharin@ibmc.msk.ru

¹Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya ul. 10, Moscow, 119832, Russia;
²Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 117984, Russia

Received: July  5, 2006;  in final form: December  14,  2006

Abstract.  (22R,23R)-22,23-dihydroxystigmast-4-en-3-one, (22R,23R)-22,23-dihydroxystigmast-4-en-3,6-dione, (22R,23R)-3β,5α,6β,22,23-pentahydroxystigmastane, (22R,23R)-5α,6α-oxido-3β,22,23-trihydroxystigmastane, (22R,23R)-5β,6β-oxido-3β,22,23-trihydroxystigmastane, and (22R,23R)-3β,6β,22,23-tetrahydroxystigmast-4-ene were synthesized. Their cytotoxicities were comparatively studied using the MCF-7 line of carcinoma cells of human mammary gland and cells of human hepatoma of the Hep G2 line.

Key words:  cytotoxicity, Hep G2 cells, MCF-7 cells, oxysterols

Russian Journal of Bioorganic Chemistry 2007, 33 (3): 326-333