Cytotoxic Derivatives of (22 R ,23 R )-Dihydroxystigmastane
F. V. Drozdov1, A. P. Mekhtiev1, G. E. Morozevich1, V. P. Timofeev2 and A. Yu. Misharin1 #
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1Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya ul. 10, Moscow, 119832, Russia; 2Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 117984, Russia
Received: July 5, 2006; in final form: December 14, 2006
Abstract. (22R,23R)-22,23-dihydroxystigmast-4-en-3-one, (22R,23R)-22,23-dihydroxystigmast-4-en-3,6-dione, (22R,23R)-3β,5α,6β,22,23-pentahydroxystigmastane, (22R,23R)-5α,6α-oxido-3β,22,23-trihydroxystigmastane, (22R,23R)-5β,6β-oxido-3β,22,23-trihydroxystigmastane, and (22R,23R)-3β,6β,22,23-tetrahydroxystigmast-4-ene were synthesized. Their cytotoxicities were comparatively studied using the MCF-7 line of carcinoma cells of human mammary gland and cells of human hepatoma of the Hep G2 line.
Key words: cytotoxicity, Hep G2 cells, MCF-7 cells, oxysterols
Russian Journal of Bioorganic Chemistry 2007, 33 (3): 326-333