A New Synthesis of Cerebrosterol and Its 24-Epimer from Lithocholic Acid

V. A. Khripach1 #, V. N. Zhabinskii1 and A. V. Antonchik1

#Phone: +375 172 648 647; e-mail: khripach@iboch.bas-net.by

1Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, ul. Kuprevicha 5/2, Minsk, 220141, Belarus

Received: March 29, 2006; in final form: April 17, 2006

Abstract.  A new method for the synthesis of both isomers of 24-hydroxycholesterol starting from lithocholic acid is proposed.

Key words:  asymmetric hydroxylation, cerebrosteroloxysterols, steroids

Russian Journal of Bioorganic Chemistry 2007, 33 (2): 258-262