New Derivatives of Alkyl- and Aminocarbonylphosphonic Acids Containing 3′-Azido-3′-Deoxythymidine

M. V. Jasko1 #, A. V. Shipitsyn1, A. L. Khandazhinskaya1, E. A. Shirokova1, P. N. Sol’yev1, O. A. Plyasunova2, and A. G. Pokrovskii2

#Phone: (495) 135-60-65; fax: (495) 135-14-05; e-mail:
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia
2Vector State Research Center of Virology and Biotechnology, Kol’tsovo, Novosibirsk oblast, 633159, Russia
Received: April 14, 2006; in final form: April 18, 2006

Abstract: New 5′-phosphonates of 3′-azido-3′-deoxythymidine were synthesized and shown to be low-toxic and markedly active in MT-4 cell cultures infected with HIV-1.

Key words: 3′-azido-3′-deoxythymidine, 3′-azido-3′-deoxythymidine 5′-H-phosphonate (Nikavir®), human immunodeficiency virus, nucleoside phosphonates

Russian Journal of Bioorganic Chemistry 2006, 32 (6): 542-546