Synthesis of Ethriolophospholipids of Acetal Type

G. A. Savin#

# Phone: (8442) 30-2896; e-mail: gasavin@mail.ru
State Pedagogical University, pr. Lenina 27, Volgograd, 400131 Russia

Received March 27, 2006; in final form, April 13, 2006.

Abstract: New analogues of acetal-type phospholipids were obtained on the basis of ethriol (2-hydroxymethyl-2-ethyl-1,3-propanediol). The starting triol originally was condensed with decanal or dodecanal to form acetals, which were then phosphorylated with tetraethyldiamidophosphorous acid chloride. The amidophosphites were further oxidized with iodosobenzene or sulfurized to the corresponding acetal-type phospholipids and their thio analogues.

Key words: acetal-type phospholipids, amidophosphites, 2-hydroxymethyl-2-ethyl-1,3-propanediol, phospholipids, thioanalogues

Russian Journal of Bioorganic Chemistry 2006, 32 (5):504-505