pH-Sensitive Cationic Lipopeptides for the Design of Drug-Delivery Systems
Yu. L. Sebyakin# and U. A. Budanova
# Phone: +7 (495) 936-8903); e-mail: email@example.com
Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571 Russia
Received December 26, 2005; in final form, March, 27, 2006
Abstract: Lipopeptides on the basis of L-glutamic acid and glutamine di- and monoesters with aliphatic alcohols of various lengths that contain L-arginine, L-ornithine, and L-lysine were synthesized. The behavior of these amphiphiles in aqueous medium was shown to depend on their structure.
Key words: cationic amphiphiles, lipopeptides, delivery systems
Russian Journal of Bioorganic Chemistry 2006, 32 (5):407-412