The Synthesis of Arginine Derivatives of Chromone and Azauracil
A. A. Poyarkov , # M. S. Frasinyuk , V. K. Kibirev , and S. A. Poyarkova
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Institute of Bioorganic Chemistry and Oil Chemistry, National Academy of Sciences of Ukraine , ul . Murmanskaya 1, Kiev , 02094 Ukraine
Received March 3, 2005; in final form, November 11, 2005
Abstract: The coupling of N-succinimide esters of 3-[7-hydroxy-3-(4-methyl-1,3-thiazol-2-yl)-6-ethyl-4-oxo-4H-chromen-2-yl]propanoic acid and 5-carboxymethyl-6-azauracil with free arginine yielded the corresponding arginine derivatives, which were purified by crystallization. The structures of the compounds were confirmed by 1H NMR spectroscopy.
Key words: arginine , azauracil , 7-hydroxychromone
Russian Journal of Bioorganic Chemistry 2006, 32 (3):277-279