The Formation and Role of β- Amyloid Peptides in Neurons upon Amyloidosis (Review)

V. M. Bairamov a , A. V. Mal'tsev b , # Yu. G. Kaminskii c , V. S. Fediukin d , and N. G. Brindar e

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a Shemyakin -- Ovchinnikov Institute of Bioorganic Chemistry , Russian Academy of Sciences , ul . Miklukho-Maklaya 16/10, Moscow , 117997 Russia
b Institute of Cell Biophysics , Russian Academy of Sciences, Pushchino , Moscow oblast, 142292 Russia
c Institute of Biological Instrumentation , Pushchino , Moscow oblast, 142292 Russia
d Immunofarm State Research Center for Practical Medicine, Obolensk , Russia
e Russian Research Institute for Gerontology, Federal Agency for Healthcare and Social Development, Tret'ya Cherepkovskaya ul . 15a, Moscow , 121552 Russia

Received July 11, 2005; in final form, October 14, 2005

Abstract: The mechanism of amyloid peptide formation in normally functioning neuron and upon the development of amyloidosis resulting in neuronal death is described. Amyloid peptides are formed by enzymatic processing of a large protein precursor and participate in intermolecular interactions after conformational rearrangements resulting in the formation of pathogenic structures. They enter into the cascade of molecular and cellular events leading to amyloidosis and death of neuronal cells. These molecular events clarify the relation between the conformation and function of neuropathogenic peptides and the role of this relation in the development of pathology of differentiated neurons.

Key words: amyloidosis ; neuronal death; neurodegenerative diseases; neuropathogenic peptides; proteins, conformational rearrangements

Russian Journal of Bioorganic Chemistry 2006, 32 (3):219-223