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The Formation and Role of β- Amyloid Peptides in Neurons upon Amyloidosis (Review)
V. M. Bairamov a , A. V. Mal'tsev b , # Yu. G. Kaminskii c , V. S. Fediukin d , and N. G. Brindar e
# Phone: +7 (0967) 739-119, e-mail: avmaltus@rambler.ru
a
Shemyakin
--
Ovchinnikov
Institute
of
Bioorganic Chemistry
, Russian
Academy
of
Sciences
,
ul
.
Miklukho-Maklaya
16/10,
Moscow
, 117997
Russia
b
Institute
of
Cell Biophysics
,
Russian
Academy
of Sciences,
Pushchino
,
Moscow
oblast, 142292
Russia
c
Institute
of
Biological Instrumentation
,
Pushchino
,
Moscow
oblast, 142292
Russia
d
Immunofarm
State
Research
Center
for Practical Medicine,
Obolensk
,
Russia
e
Russian Research Institute for Gerontology, Federal Agency for Healthcare and Social Development,
Tret'ya
Cherepkovskaya
ul
. 15a,
Moscow
, 121552
Russia
Received July 11, 2005; in final form, October 14, 2005
Abstract: The mechanism of amyloid peptide formation in normally functioning neuron and upon the development of amyloidosis resulting in neuronal death is described. Amyloid peptides are formed by enzymatic processing of a large protein precursor and participate in intermolecular interactions after conformational rearrangements resulting in the formation of pathogenic structures. They enter into the cascade of molecular and cellular events leading to amyloidosis and death of neuronal cells. These molecular events clarify the relation between the conformation and function of neuropathogenic peptides and the role of this relation in the development of pathology of differentiated neurons.
Key words: amyloidosis ; neuronal death; neurodegenerative diseases; neuropathogenic peptides; proteins, conformational rearrangements
Russian Journal of Bioorganic Chemistry 2006, 32 (3):219-223