New Ceramides from Sea Sponge Oceanapia sp.

A. G. Guzii ^a , T. N. Makarieva ^{a #} , V. I. Svetashev ^b , V. A. Denisenko ^a , P. S. Dmitrenok ^a , E. V. Pokanevich ^a , E. A. Santalova ^a , V. B. Krasokhin ^a , and V. A. Stonik ^a

^# Phone: +7 (4232) 31-1168, fax: +7 (4232) 31-4050, e-mail: makarieva@piboc.dvo.ru
^a Pacific Institute of Bioorganic Chemistry , Far-East Division, Russian Academy of Sciences, pr. 100-letiya Vladivostoka 159, Vladivostok , 690022 Russia
^b Institute of Marine Biology , Far East Division, Russian Academy of Sciences, ul . Pal'chevskogo 17, Vladivostok , 690041 Russia

Received May 16, 2005; in final form, August 1, 2005

Abstract: Total ceramides containing nonbranched and iso-branched C₁₈- and C₁₉-phytosphingosines acylated with nonhydroxylated fatty acids were isolated from a marine sponge Oceanapia sp. The structures of these compounds were determined by HPLC, NMR, MALDI TOF MS, and GLC-MS of the Me@3Si derivatives and by chemical transformations.

Key words: ceramides , GLC-MS, NMR, MALDI TOF mass spectra, marine sponge, Oceanapia sp., TMS derivatives

Russian Journal of Bioorganic Chemistry 2006, 32 (3):288-294