Polymethyleneamine Alkaloids of Animal Origin: II. Polyamine Neurotoxins

L. N. Rogoza,# N. F. Salakhutdinov, and G. A. Tolstikov

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Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 9, Novosibirsk, 630090 Russia

Information on the structure and biological activity of animal alkaloids, polymethyleneamine components of spider and wasp venoms, is considered and systematized. These natural compounds are used for the development and modification of medicines for treating the functional disturbances in the central nervous system of humans.

Key words: acylpolyamines , biological activity, marine metabolites, microbial metabolites, polymethyleneamines , synthetic analogues

Received March 2, 2004; in final form, April 4, 2005

Russian Journal of Bioorganic Chemistry 2006, 32 (1):23-36